Welcome back everybody to the long awaited sequel to my most popular video of all time, the BEST SYNERGIES for Brimstone in the Binding of Isaac REPENTANCE! Items character damage multipliers), This item can only reduce your heart containers and will not increase them if you change back into a character with more health. The charge time is based on your tears stat. It gives you 2 seconds to pick it up again to re-heal, before it disappears, UNLOCK: Unlock this item by defeating Delirium as Tainted Magdalene, Whenever you deal damage to an enemy, has a chance to give the effect of one of Tainted ??? Chapters 25 Of The Best Items In The Binding Of Isaac. Item Pool: Item Room, Demon Beggar, Lust Miniboss, * demon beggar pool, demon judgement pool, devil beggar pool, item room, treasure room, item room pool, syringe, needle, injection, the lost item pool, red, Item Pool: Item Room, Boss Room, Demon Beggar, * demon beggar pool, demon judgement pool, devil beggar pool, boss room pool, boss room item, item room, treasure room, item room pool, syringe, needle, injection, green, Has a chance to drop from the Gluttony miniboss fight, * boss room pool, boss room item, item room, treasure room, item room pool, red heart, ballchinnian, ball sack, full heal, gluttony, the lost item pool, * secret room pool, the lost item pool, brown, poop, turd, * secret room pool, silver, grey, gray, skull, Can drop from an exploding slot machine while playing it, * slot machine, arcade machine, money, bill, cash, green, * boss rush pool, boss rush room, item room, treasure room, item room pool, grey, gray, x10, UNLOCK: Unlock this item by beating Mom's Heart 3 times, * secret room pool, the lost item pool, brown, noose, hang, Shows most icons on the map (Shops, Item Rooms, Boss Rooms etc. Brimstone is a passive item. The Knife Piece 1 is located in the Item Room in the mirrored area. ?, as they cannot gain red heart containers (except for counting towards the Spun transformation), REPENTANCE - Adrenaline now grants an increasingly higher damage bonus the more empty heart containers Isaac has, * Adderline, pink, syringe, needle, injection, Isaac gains electric tears, which fire 1-2 sparks of electricty in random directions upon hitting any object or enemy, The electricity will chain between nearby enemies, The electricty deals half of your normal tear damage, Tear effects will still apply to your electricty sparks in a lot of cases. The split tears are affected normally by shot speed. Kicking a frozen enemy will push it into the wall, where it shatters and fires ice shards everywhere (these can then freeze other enemies), Enemies touching the cube while it's not moving or moving slowly will become slowed for a few seconds, and take a small amount of damage, Cube Baby and enemies frozen will block enemy shots, Cube Baby can be launched across the room if you have a melee weapon, Enemies that die now spawn a red ghost, that floats in place of where the enemy died, Activating the item causes all red ghosts in the room to explode, dealing damage to any enemies near them, The explosion doesn't deal damage to Isaac, Damage dealt by each ghost is 3 + 0.04x the HP of the enemy it spawned from, Larger enemies such as minibosses will spawn a larger red ghost that causes 3 explosions, The red ghosts can be moved around slightly by firing tears through them, Using the item will instantly kill any enemy or boss that has the 'ghost' tag and is at 50% or less HP. (Blue baby), *, dead, blue, face, fates reward, fate reward, A familiar chest that follows Isaac and has a 25% chance to drop a pickup after clearing a room, Possible drops include hearts, coins, bombs, key, pills, card, runes, batteries, trinket, UNLOCK: Unlock this item by beating Greed Mode with Isaac, Item Pool: Item Room, Greed Mode Item Room, Beggar, An orbital angel which does 7 contact damage per tick and blocks shots, The angel will attract bullets towards it and block them, Sworn Protector will drop an eternal heart if it blocks 10 shots in one room. Curse of the Lost), Black Candle removes the teleportation effect of Cursed Eye, +15% chance of a devil or angel room opening after the boss fight, UNLOCK: Unlock this item by donating 150 pennies to the Shop, * curse room pool, shop room pool, shop item pool, grey, gray, Gives Isaac high damage tears with a short range, Tear size and damage falls off very fast with this item, the further the tear travels the less damage it does, Tear damage starts at triple (300%) and decreases over range to eventually be 0%, * item room, treasure room, item room pool, red, bloody, eyeball, If the total sum of all your health is at one heart after taking damage, the necronomicon effect will activate, dealing 40 damage to the entire room, REPENTANCE - Missing Page 2 now doubles all black heart and Necronomicon damage (to 80 instead of the usual 40), Item Pool: Devil Room, Demon Beggar, Secret Room, * demon beggar pool, demon judgement pool, devil beggar pool, secret room pool, devil pool, devil room pool, devil deal, the lost item pool, red, bloody, purple, paper, A yellow orbital fly that will block shots and when Isaac gets hit, will seek out the nearest enemy and attack it, If the fly is in its attacking state and there are no longer any enemies in range, it will return to Isaac and go back to being a defensive orbital, * key master pool, key beggar pool, key judgement pool, item room, treasure room, item room pool, sudden breathlessness, sharp chest pain (may be worse when you breathe in) and a cough or coughing up blood. from Fireplaces, Gives you a familiar which is a smaller version of the Plum boss, which sprays tears and propels itself around the room, Deals 2 contact damage per tick to enemies, and the tears deal 3 damage each, Deals contact damage to any enemies it runs into, UNLOCK: Unlock this item by beating Baby Plum 10 times, When used, this item calls a friendly version of the Plum boss to fight for you for 10 seconds, It will jump to the nearest enemy, slam on the ground and fire tears around it, then propel itself around the room, dealing contact damage to any enemies it touches before disappearing, It's possible to get a guaranteed spawn of this item by encountering the Baby Plum boss and not damaging her. Each laser is emitted for about one second and hits twice, so it is possible to destroy some two-stage enemies in one shot (Globins and Hives along with the flies they spawn on death), or to strafe the shot over multiple enemies. UNLOCK: Unlock this card by beating Challenge #12 (When Life Gives You Lemons), When used, will open all doors in the current room, similar to a one-time use of Dad's Key, UNLOCK: Unlock this card by beating Challenge #22 (Speed), When used this card will activate a use of your spacebar item for free, When used, this rune will destroy all breakable objects in the current room, such as poop, rocks, secret room entrances, UNLOCK: Unlock this card by beating Challenge #1 (Pitch Black), When used this rune will double all pickups on the floor in the room, Creates copies of pickups in the Shop which can be taken for free, even if you haven't purchased them yet, Can be used to double the number of item chests in the first room of the final Chest / Dark Room floors, Cloned chests have the same types of items as the first one, Cannot be used to clone trinkets or other Jera runes, UNLOCK: Unlock this card by beating Challenge #2 (High Brow), UNLOCK: Unlock this card by beating Challenge #3 (Head Trauma), Removes the curse which is in effect on the current floor (except Curse of the Labyrinth), Can also cure the effect of the Amnesia pill, UNLOCK: Unlock this card by beating Challenge #4 (Darkness Falls), When used, reveals the entire map including all the secret room locations and other icon rooms, UNLOCK: Unlock this card by beating Challenge #5 (The Tank), Rerolls all pedestal items in the current room (One time use of the D6), UNLOCK: Unlock this card by beating Challenge #6 (Solar System), Summons 3 blue friendly spiders and 3 blue flies, UNLOCK: Unlock this card by beating Challenge #20 (Purist), When used, gives you an invincibility effect which lasts for 20 seconds, UNLOCK: Unlock this card by beating Challenge #8 (Cat Got Your Tongue), When used, gives a random Mystic rune effect, Possible effects include: Algiz, Ansuz, Berkano, Dagaz, Ehwaz, Hagalaz, Jera, Perthro, Also has a 25% chance to spawn another Blank Rune upon use, UNLOCK: Unlock this card by beating Challenge #30 (Guardian), When used, this rune deals 40 damage to all enemies in the room and consumes all pedestal items in the room, giving you a random stat increase for each item consumed, Also consumes all pickups in the room and turns them into blue flies and spiders, UNLOCK: Unlock this item by beating Greedier mode as Apollyon. Blood clots can have d. Soul Hearts that are used to charge Spirit Shackles will not be added to your health as normal, UNLOCK: Unlock this item by defeating The Beast as The Forgotten, Taking damage reveals a random room on the minimap, and automatically opens certain doors in the current room. Objects Trinkets - Gives the curse of the maze effect for the current floor. Deals 45 damage to enemies it lands on. Recharge time: Starts at 1 second, increasing by every time you use it. Seeds . If a pushed enemy hits a rock or wall forcefully enough, they take 10 damage, UNLOCK: Unlock this item by destroying 100 poops, * normal beggar pool, normal judgement pool, coin beggar pool, coin judgement pool, item room, The poison deals your tear damage per tick, for 2 ticks, Has no effect on Lilith, as she cannot fire tears, While firing tears constantly for 7.5 seconds, you spawn a poop cloud, which deals periodic damage to any enemies which come near it, The cloud deals damage equal to your base tear damage per tick, roughly 5 times per second, Clouds last 15 seconds before disappearing, The cloud can be pushed slightly by firing tears at it, Upon taking damage, Isaac starts to bleed, leaving a trail of blood and spraying blood tears everywhere which deal damage to nearby enemies, While bleeding, Isaac takes damage every 30 seconds, The blood sprays in the direction you are current firing, or just randomly near Isaac if not shooting your tears, The blood spray scales with your current tear damage and any future damage increases, This effect lasts until you pick up a red heart, Upon taking damage, this item gives a 25% chance to drop a full red heart, REPENTANCE - This entire item has been reworked, Enemy bullets have a 25% chance to be deflected back at the enemy, which will hurt them and apply the concussive status effect, causing it to be stunned for a few seconds, Every 20th tear fired will also fire a golden coin tear at the same time. Will take red hearts first before any other, Eve starts with this item after donating 439 coins to the Greed Donation Machine, UNLOCK: Unlock this item by beating Satan with Eve, Item Pool: Item Room, Curse Room, Demon Beggar, * devil pool, devil room pool, devil deal, the lost item pool, starting, silver, grey, gray, Upon use, this item refreshes the current floor with brand new rooms, monsters and items, as if you had entered a new floor, UNLOCK: Unlock this item by beating Satan with Blue Baby, Item Pool: Item Room, Secret Room, Devil Room, Demon Beggar, * secret room pool, item room, treasure room, item room pool, pill, tablet, drug, white, Bosses Stat Up becomes Stat Down), Any 'Stat down' pills you take give you a permanent +0.6 Damage Up (Horse pills +1.2), Most other pills spawn a black heart when used, including R U A Wizard?, Amnesia, Bad Trip, ?? The damage done by Glass Cannon is calculated as follows: dmg = (dmg * 10) + 10 (i.e. Azazel- Azazel gets Brimstone, The Ludovico Technique, Cricket's Head, Demon Tail, and 1 red heart. REPENTANCE - Brown Nugget flies now have faster shot speed, and their damage has been increased to 3.5 (from 2). This is to prevent a syngery like Dr. Fetus or a Golden Bomb giving you infinite resources, Isaac's shadow will follow closely behind him and when it comes into contact with enemies, will spawn friendly dark charger mobs, The chargers deal contact damage to enemies, and will be killed if it is hurt too much, Chargers disappear upon entering a new room, UNLOCK: Unlock this item by beating Greed Mode with Judas, Every time you kill an enemy a fly will be added to the Jar, allowing you to stack up to 20, Using the Jar of Flies will release all the flies that are currently in the jar as friendly flies that will damage enemies, A Loki familiar that follows Isaac and shoots tears 4 tears in a cross pattern, dealing a flat 3.5 damage each, Gives Isaac a familiar glass of milk that follows him and spills on the floor upon taking damage, After being spilt, the milk gives you a -2 Tear Delay (Tears up) for the rest of the room, When used, the D7 will restart the current room and bring back all enemies once again, enabling you to farm rewards that spawn at the end after beating the room, Can be used to generate infinite consumable combinations, gaining as many coins/keys/bombs as you need, This item has no effect in Greed Mode, Challenge Rooms and rooms that had no enemies in originally, If used in a Boss Room or Angel/Devil Room, you get teleported to another random room, which is reset instead of the boss/angel/devil room you were in, Enemies respawned by the D7 don't drop loot if they were champions and also don't grant score in daily runs, * dice, pip, die, turban, white, grey, gray, Makes Isaac very small like a baby, reducing his hitbox size, When used, Mom's Box will drop a random trinket on the ground, While held, doubles the effect of trinkets which make sense to be doubled (e.g. Each brimstone laser deals 8 damage per tick for 13 total hits. Unlock Method Entity ID yellow book how to, * boss room pool, boss room item, bone, red, brown, Gives Isaac a random tarot card when picked up, * boss room pool, boss room item, eight, grey, gray, Drops 4 random pills on the floor around Isaac, Item Pool: Shop, Boss Room, Challenge Room, Beggar, Demon Beggar, Mom's Chest, * dungeon room, blood challenge room, arena pool, demon beggar pool, demon judgement pool, devil beggar pool, normal beggar pool, normal judgement pool, coin beggar pool, coin judgement pool, boss room pool, boss room item, shop room pool, shop item pool, bag, pouch, moms coin purse, mom coin purse. This brings you to the maximum possible speed, The effect lasts for the rest of the current floor, UNLOCK: Unlock this item by defeating Mother as Samson, Isaac gains a halo of light around him. Enemies that are killed by the ice tears will become frozen, Frozen enemies never unfreeze and are considered dead by the game. Characters Blood clots can have different appearances, stats and effects based on the type of heart they were created from.There are currently 7 types of blood clots available in the game. Doesn't work with Chocolate Milk. Doing this will cause this Golden Battery to reappear somewhere else on the floor, UNLOCK: Unlock this by defeating Mega Satan as Tainted Forgotten, Spawns similar to regular troll bombs and cannot be picked up, However, they will explode forever instead of disappearing, The Safety Scissors trinket will turn this into a gold bomb, When picked up, will respawn again at a random location in the room, Every time you pick up a golden penny it has a 5% chance to disappear completely, UNLOCK: Unlock this by defeating Mega Satan as Tainted Keeper, Once picked up, the gold heart will drop money on the floor the next time Isaac loses a heart, UNLOCK: Unlock this item by beating challenge #21 (XXXXXXXXL), Takes three hits to deplete and can be refilled with red hearts, but disappears forever when depleted, UNLOCK: Unlock this item by unlocking the Forgotten character. item room pool, question mark book, white, When used, spawns 4-8 friendly blue spiders on the floor, REPENTANCE - Used to give 1-4 spiders per use, * item room, treasure room, item room poolgrey, gray, Allows you to fire a red flame infront of you, similar to the Blue Candle item, however the flame will stay 10 seconds, Each flame deals 125 total damage before it disappears, The flame will shrink in size when deals damage to something and eventually disappear, REPENTANCE - Red Candle flames now time out after ten seconds and automatically extinguish. Every 6 coins Bumbo will evolve to a new form except for level 4 which takes 12 coins, Level 2: Bumbo gains a body and crawls around the room, sometimes dropping random pickups, Level 3: It now fires tears in the same direction Isaac does, Level 4: Bumbo no longer fires tears but instead will chase enemies slowly and deal contact damage. Tap the drop button to cycle between each one, All future pill drops will now instead become cards, * shop room pool, shop item pool, packet, deck, brown, orange, Allows for 2 pills to be held. She is the alternate version of Eve with ragged hair, no bird, and ruined mascara as if crying, and an occasional cosmetic blood trail. Haemolacria's appearance in the original Steam Workshop mod. One of the sounds lasers can make when synergizing with Monstro's Lung. This doesn't work with The Lost characters, While in a room with enemies, red cracks will appear on the floor in random locations, Walking over the crack spawns a white soul familiar, that launches itself into the nearest enemy, exploding and dealing double your tear damage to everything near it, Cracks will keep appearing but only one can exist in the room at a time, UNLOCK: Unlock this item by defeating challenge #38 (Baptism by Fire), While held, this item spawns a familiar that can be moved around using the arrow keys and deals 1.5 damage per tick to any enemies it touches, When activated, you teleport, swapping places with wherever Stitches was positioned, Teleporting next to fires will extinguish them (including blue fires) and on top of shopkeepers will destroy them (gives +10% devil/angel room chance as normal), If used while stitches is on top of an enemy, it can be used to telefrag enemies, dealing x3.5 your damage + 40, Can be used to enter/exit Curse Rooms for free by teleporting infront of the door while holding the direction key to move in immediately. Item Pool: Item Room, Secret Room, Crane Game, Taking damage for the first time in a room spawns a familiar which targets an enemy and jumps on them, releasing a rock wave outwards, For the remainder of the room the familiar then continues to attack enemies similar to the Dead Bird item dealing 3 contact damage per tick. After dealing enough damage it will eventually disappear, At full size the flame deals 6x your tear damage, scaling down to 3x at its smallest size, The chance to for each tear to become a flame is affected by your luck stat and at +10 Luck it will activate 50% of the time (starts at 8.33% at +0 Luck), Each tear now has a small chance (3.33%) to be a needle instead, which deals 3 times your tear damage, If a needle hits a non-boss enemy it will instantly kill it and will explode into a circle of 10 more needles, The 10 spawned needles will also deal 3 times your tear damage, but won't instantly kill enemies or explode into more needles, The chance to for each tear to become a needle is affected by your luck stat and at +15 Luck it will activate 50% of the time, UNLOCK: Unlock this item by defeating Delirium in The Void floor with Lilith, *, black, syringe, injection, euthansia, dang, dan gheesling, dangheesling, dangDEB8, you piece, Upon entering a new room, Isaac will become camouflaged and enemies won't attack until you start firing tears, Camo Undies grants +0.5 speed while cloaked, When uncloaking, all nearby enemies take damage, and Isaac gains a brief tears + damage up, *, pink, purple, goggles underwear under wear, Any time a devil or angel room door opens after a boss, the other one will also spawn, The extra door will only spawn if a devil or angel room was randomly chosen to spawn already, After entering one of the doors, the other will disappear, If there isn't an available wall for the extra door to spawn on, only one door will spawn (i.e. Flies spawned from a Mulligan dying, When used, the Mega Bean will freeze all enemies in the current room for a couple of seconds, deal 5 damage and poison any enemies in close proximity and send a wave of spikes across the room in the direction you are facing, The enemies in close range will take 5 damage then have a poison over time effect which deals your tear damage 4 or 6 times, The spike wave will deal 10 damage to any enemies in contact with it. When used, it retrieves the Forgotten skull, causing it to shoot back into your arms, Tainted Bethany - Spawns four random item wisps of high quality with significantly higher HP than normal, Tainted Jacob - Dark Esau splits into 2. Ultra Secret RoomTreasure RoomTreasure Room Isaac Hanson joined legislators and health officials . Each poop has random effects like Butt Bombs, Fire Poops etc, Tainted Blue Baby starts with this item, and is the only one who can use it, Spawns 3 random coins and a key when picked up, Buying items from the shop gives you random stat upgrades. As Azazel they fire brimstone and as The Forgotten they use a bone club, At the beginning of all future floors, two portals will appear, that can take you to either the Boss room (Red portal), Item room (Yellow portal) or Secret room (Blue portal), After Chapter 3 (The Depths floors) only one portal will spawn, Portals disappear if you leave the starting room, Every time an enemy dies, a random familiar spawns where it was killed for the rest of the room, The familiar cannot move, but continues to do its usual abilities, Possible familiars include: Abel, Boiled Baby, Brother Bobby, Sister Maggy, Little Steven, Demon Baby, Multidimensional Baby, Freezer Baby, Rotten Baby, Harlequin Baby, Ghost Baby, Guardian Angel, Lil Brimstone, Robo-Baby and Seraphim, Every 5 seconds you become spiky for a second, becoming immune and dealing 40 contact damage to any enemies that touch you, The effect is indicated by 4 white flashes, where the item activates on the 4th flash, If timed well, can be used to enter curse rooms and open spiky chests without taking damage. Chapters the lost item pool, grey, gray, A familiar which follows Isaac and shoots spectral tears that deal 3.5 damage, Ghost Baby fires tears at a rate of 1 tear per second, Can drop while destroying skulls in the Depths and Necropolis floors, * devil pool, devil room pool, devil deal, item room, treasure room, item room pool, white, spoopy, A spacebar item which allows Isaac to fire a blue flame that damages anything in its path for 23 damage per tick, Can cause up to a total of 276 potential damage, The flame destroys enemy shots, making it useful for bullet hell bosses, UNLOCK: Unlock this item by donating 900 coins to the Shop, * shop room pool, shop item pool, blue candle, grey, gray, silver, lamp, lantern, * boss room pool, boss room item, grey, gray, whip, cat o nine tails catonine tails, Upon use, re-rolls all pickup consumables in the current room into another random kind of pickup, This includes all types of pickup such as hearts, bombs, keys, coins, pills, tarot cards, chests, trinkets etc, UNLOCK: Unlock this item by beating the Chest with Isaac, * item room, treasure room, item room pool, dice pip, red, A familiar which follows Isaac and shoots two normal tears at once in a V-shaped pattern, Each of Harlequin Baby's tears deal 4 damage, Harlequin Baby fires tears at a rate of 1 tear per second, * item room, treasure room, item room pool, bug, eyes, pink, red, Tears now become missiles which deal huge damage to anything nearby, This item places a controllable red target on the ground which will cause a missile to fall from the sky and hit it after a short period of time, UNLOCK: Unlock this item by beating Challenge #19 (The Family Man), Item Pool: Secret Room Item Room (very low weight), * item room, treasure room, item room pool, fetus in a jar, bug, white, hat, pink, If a tear kills an enemy, it continues to travel forward with the leftover damage, * item room, treasure room, item room pool, large eye, cyclops, one eye, blue, white, A shadow follows Isaac and stomps on enemies randomly, dealing 40 damage per stomp (2 damage ticks at 20 damage each), * item room, treasure room, item room pool, white, yarn, wool, spider, Upon use, does 10 damage to all enemies in the room and gives them a slowing effect for 4 seconds, REPENTANCE - Enemies killed by Spider Butt will now spawn friendly blue spiders, * item room, treasure room, item room pool, brown, red, web, Gives Isaac an orbital knife that blocks shots and deals 15 damage per tick on contact with enemies, The highest damage orbital in the game, dealing 225 damage per second, Synergises very well with invulnerability items such as Book of Shadows, UNLOCK: Unlock this item by beating the Chest with Eve, * devil pool, devil room pool, devil deal, item room, treasure room, item room pool, bloody, Is based on your tears stat speed, and 1 red heart has! 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