I also have a 5 month Aussie who the current vet has on Bravecto 1-month and TriHeart. Before I got them home, they went into comas. These three are listed as a new group of drugs called Isoxazolines, and are neurotoxins. (MDR1 -/-) following single oral administration at 5 times the recommended dose. Both of those products should definitely be more effective than the Frontline Plus. They were extremely helpful people. Personally, my Roughs have sensitive skin plus I have a household cat, so Id try Frontline Gold first. This is typically due to a specific genetic mutation (MDR1) that makes them less able to tolerate high doses of ivermectin. Tap to zoom. We recently switched our dogs to a new product called Simparica Trio. Hi there , thank you for putting this information up! Hi, I was just wondering if you still use credelio for flea prevention? Remember she is fixed. Any thoughts on either of these? Either Sentinel or Interceptor are generally considered safe for Collies and can be used to treat demodectic mange. I just picked out a beautiful tri color rough collie this morning! Im sincerely grateful!! Altogether, the agency received 75,000 incident reports, the majority of which were complaints of skin reactions in both animals and humans. I appreciate the research in this thank you! 2022 Collie Chatter. Any dog can have a sensitivity to a certain substance and should always be monitored for reactions after a new product has been administered. Simparica Trio 11.1-22 lbs. If your Collie doesnt play like that, you should be fine. Their lower cost makes them appealing for those of us living life on a budget, but its worth it to spend just a little more for your canines safety. Two dogs were positive for D. immitis antigen but not MF on days 210 and 236. The product was well tolerated in dogs with a deficient multidrug-resistance-protein 1 (MDR1 -/-). I need to pivot, and looking at Frontline there are two new Frontline products to combat the flea resistance. Happy to help! We have a almost 10 year old tricolor rough collie, named Hollie. GestorVet es el futuro de la gestin veterinaria. Hello! My question is about Capstar. Evoluciona. It provides 100% protection from heartworm disease. For years she was taking Sentinel for both heart-worm and tick prevention. Happy to help! Dogs with normal MDR1 genes can usually tolerate oral dosages as high as 2,500 mcg/kg of body weight before signs of toxicity are seen, while dogs with two copies of the defective MDR1 gene can tolerate only up to 100 mcg/kg of oral ivermectin. I never knew flea/tick control was so complicated, until I started reading! Theres less risk of reaction with Interceptor, so I wouldnt switch unless theres a good reason to do so. We can eat it. 3,4,7-9 Most notably, a series of randomized . Anyway, we have a lot of lyme disease here in Wisconsin so we need a good tick preventative. My veterinarian, knowing of Yoshis MDR1 gene status, specifically recommended Credelio as a safe option because she was suffering from a terrible flea allergy. Dimmitrol is available from Pets Megastore, which ships to Australia, Canada, the UK, and the USA. Regarding seizures specifically: Nexgard averaged 263 reported per year, Simparica averaged 186 reported per year, and Bravecto averaged 180 reported per year. Thankfully he recovered but my vet tells me Interceptor Plus is safe and he must have ingested something on his walk. Additionally, it can be used to treat and control sarcoptic mange. Any of the above scenarios can cause real problems due to an unintended overdose. (One such knockoff, Pet Armor Plus, is even available at Walmart.). Is hartz ultraguard ear mite treatment for dogs safe? Many veterinary clinics keep some in stock for their clients, and it is also available at online stores like 1-800-PET-MEDS or Chewy. I can live with that. The US Food and Drug Administration (FDA) issued a warning on September 20, 2018 about the isoxazoline flea and tick products fluralaner for dogs and cats (Bravecto), afoxalaner for dogs (Nexgard), and saroloner for dogs (Simparica). Their cheek swab collection, multiple dog discounts, and printable results sent straight to email all make the process very simple and convenient. I been debating which one to use on my BC and small BC mix for ticks as well as prevention of Mites, which seem to increase in numbers with the ever increasing number of Coyotes we see these days. Class A DO NOT use these drugs in dogs with the MDR1 Gene Defect Ivermectine substances "Anti parasites": (Diapec, Ecomectin, Equimax, Eqvalan, Ivomec, Noromectin, Paramectin, Qualimec, Sumex, Virbamec) Doramectine substances "Anti parasites": (Dectomax ) The effects of the mutation vary in severity, depending on whether the dog carries one or two copies of the mutation. Im glad you found it helpful. Nothing could be done for them. Tap to zoom. This is typically due to a specific genetic mutation (MDR1) that makes them less able to tolerate high doses of ivermectin. Im happy to hear you found it helpful! Australian Shepherds, along with several other mostly collie-type breeds, can carry a genetic mutation that makes them sensitive to certain drugs. Permethrin is a synthetic of Pyrethrin, which is derived from the chrysanthemum flower. These can come in a few different forms: monthly spot-on, a disposable collar, or a spray. (For those who may be wondering, the mutant/normal designation means that a dog carries one copy of a gene and is a carrier, though not affected to the degree that a homozygous, or mutant/mutant, dog would be.) But of course, do talk to your vet and see what they know. Ive got Advantage Multi marked as Use with Caution since Moxidectin can have harmful effects on a dog with MDR1 if ingested. Thank you so much for writing this article and for the information you provided. It has been demonstrated to be safe for puppies as young as 8 weeks old weighing 2.8 pounds or more. Zoetis (Simparica, Revolution Plus): 888-963-8471; If you prefer to report directly to the FDA, . My Aussie/Pyrenees mix has had no issues with it, for instance. Thank you for the research and the detailed info on each product. Its simpler to identify medicines by their components, since many of them are essentially the same thing marketed under different brand names. Were bringing home an MDR1 heterozygous smooth boy this weekend so Ill definitely be saving the link to this page. I myself have successfully used both on my 2 Collies and my Aussie mix with no ill effects. This paper detailed a study done using 16 collies, eight males and 8 females. SIMPARICA TRIO (sarolaner, moxidectin, and pyrantel chewable tablets) is a flavored, chewable tablet for administration to dogs 8 weeks of age and older. Happy to help! Revolution and Stronghold even tested safe over the recommended monthly dosage for dogs with the MDR1 gene, and they hold the distinction of being the only heartworm meds that did not produce any negative drug reactions. Thank you for the positive feedback. However, the medicine can be passed through a mothers milk: so it is not recommended for pregnant or nursing female dogs, though it is safe for puppies 8 weeks of age and older. Very recently, significantly increased brain penetration of fluralaner was demonstrated in an mdr1 mutant mouse model, indicating that MDR1-mediated drug efflux normally prevents fluralaner entry into the brain [ 21 ]. Some parts of the U.S. now report a new strain of survivor flea that has developed a resistance to fipronil, the main ingredient in Frontline. However, it does claim to kill fleas on contact. Simparica Trio is generally well tolerated at the recommended dose; adverse reactions (t ransient ataxia and/or muscle fasciculation in dogs with a deficient multidrug -resistance-protein 1 (MDR1 -/-)) are only seen at overdoses. 1 x 40mg tablet for 22.1 to 44 pounds. Happy to help! I understand that most dogs are not having negative side effects as a result of using Bravecto, Nexgard, or Simparica but enough dogs are. Honestly, I think K9 Advantix would beat Credelio as far as effectiveness, due to its repellent properties and ability to kill on contact. As far as which flea and tick protection would be safest for a puppy, some of my top picks are Capstar (for instant relief, not necessarily long-term use), a natural oil spray like Natural Chemistry or Wondericide, or something not very harsh like Frontline Plus. This year she has a very high degree of irritation when applied (I had to wash it off). Giardia can be passed to and cause diarrhea in humans. As with everything else, monitor your dog for symptoms. Im going to order some of the organic spray to help. However, I have to state the disclaimer that even parasite protection products officially labeled safe from an MDR1 standpoint should really be designated safe-ish. Most of these products are chemical compounds, and as such have more potential to cause a reaction than just, well, water. The neurological problems tied to Simparica scare the shit out . Frontline Plus targets four kinds of ticks, fleas (including eggs and larvae), lice, and mites that cause sarcoptic mange. Trish. All the available heartworm medications on the market are a variation of what is known clinically as a ML (macrocyclic lactone) compound. The collar releases no odor or residue, comes with a quick release catch to prevent accidental choking, and even has safety reflectors. For instance, some MLs are best tolerated when orally ingested, which meant that a pill form of that particular compound was developed; but moxidectin was just the opposite. (I have to give them baths with a very mild or medicated shampoo.) Our vet recommended Bravecto because he said it had been specifically tested on dogs with the MDR1 gene. I grew up in Michigan, and we always discontinued pest products during the cold season. The emphasis of this article will continue to be on safety, though I have no doubt as to the efficacy of certain pest preventives over others. Thank you for your article. She is just 1 year old. Anecdotally anyway, it is reported to have gentler ingredients and the least tendency to cause skin irritations. Thanks for your efforts to help! I cannot express how happy I was to come across this article, so thank you for writing it! The caution is specifically for cats since Advantix contains Permethrin, which is toxic to them. Id like to thank you so very much for this in depth article. I am going to try WonderCide as recommended by my Vet for fleas. Great Treats for Collies (Easy on the GI Tract), This article (authored by two veterinarians) is an excellent resource, it could suffer severe side effects and even die, this article I wrote about Border Collies, available online from pet supply stores such as Chewy, a link to a USA Today article about side effects resulting in seizures and even death, the USA Today headline (I get notifications on my phone) about Seresto collars. Simparica 5 mg chewable tablets for dogs 1.3-2.5 kg Simparica 10 mg chewable tablets for dogs >2.5-5 kg . Giardia can be passed to and cause diarrhea in humans. Still be careful to monitor for skin reaction if you try the Frontline Gold, too. Went into comas the product was well tolerated in dogs with the MDR1.... A quick release catch to prevent accidental choking, and even has safety reflectors reactions after a new group drugs. The flea resistance pounds or more done using 16 Collies, eight and! Males and 8 females some in stock for their clients, and neurotoxins. Essentially the same thing marketed under different brand names: monthly spot-on a... Organic spray to help knockoff, Pet Armor Plus, is even available at online like. To prevent accidental choking, and it is reported to have gentler and... Of reaction with Interceptor, so thank you so much for this in depth article stores like 1-800-PET-MEDS or...., or a spray on the market are a variation of what is known clinically a. 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